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Sunday, September 30, 2012
quemacontece: O corpo de @hebeoficial est? saindo da casa dela agora, rumo ao Pal?cio dos Bandeirantes, onde ser? o vel?rio. Informa??es em breve!
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Source: http://twitter.com/quemacontece/statuses/252164614714966017
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Bombs target Shiite areas, security forces in multiple cities across Iraq, killing 26
BAGHDAD - Bombs striking Shiite neighbourhoods, security forces and other targets across Iraq killed at least 26 people Sunday, officials said. It was the latest instance in which insurgents launched co-ordinate attacks in multiple cities across the country in a single day, apparently intending to rekindle widespread sectarian conflict and undermine public confidence in the beleaguered government.
The deadliest attack came in the town of Taji, a former al-Qaida stronghold just north of Baghdad, where three explosive-rigged cars went off within minutes of each other. Police said eight people died and 28 were injured in the back-to-back blasts that began around 7:15 a.m.
In all, at least 94 people were wounded in the wave of attacks that stretched from the restive but oil-rich city of Kirkuk in Iraq's north to the southern Shiite town of Kut.
There was no immediate claim of responsibility for the violence, but car bombs are a hallmark of al-Qaida in Iraq. The Sunni militant network has vowed to take back areas of the country, like Taji, from which it was pushed before U.S. troops withdrew last December.
Shortly after the Taji attacks, police said a suicide bomber set off his explosives-packed car in the Shiite neighbourhood of Shula in northwest Baghdad. One person was killed and seven wounded. Police could not immediately identify the target.
"So many people were hurt. A leg of a person was amputated," lamented Shula resident Naeem Frieh. "What have those innocent people done to deserve this?"
And in Baghdad's bustling Karrada neighbourhood, a parked car laden with explosives went off next to a police patrol, killing a police officer and a civilian, other officials said. Eight other people were injured. The blast was followed minutes later by another parked car bomb as people gathered, killing three civilians and injuring 12 others, they added. Secondary bomb blasts targeting those coming to help the wounded are a common insurgent tactic.
Elsewhere in the country, another suicide bomber drove a minibus into a security checkpoint in Kut, located 160 kilometres (100 miles) southeast of Baghdad. Three police officers were killed and five wounded, Maj. Gen. Hussein Abdul-Hadi Mahbob said.
And in Iraq's north, another policeman was killed when security forces were trying to defuse a car bomb parked on the main highway between the cities of Kirkuk and Tuz Khormato, said Kirkuk police chief Brig. Gen. Sarhad Qadir. A second policeman was wounded in the blast, Qadir said. Kirkuk is about 290 kilometres (180 miles) north of Baghdad.
In mid-morning, another parked car bomb went off next to a bus carrying Iranian pilgrims in the town of Madain, killing three Iraqis and injuring 11 others included seven Iranians, another police officer and health official said. Madain is a mainly Sunni area located 20 kilometres (12 miles) southeast of Baghdad.
In the town of Balad Ruz, 75 kilometres (45 miles) northeast of Baghdad, a parked car bomb targeted a passing police patrol, killing two policemen and injuring seven others, a police officer and health official said. And in the nearby town of Khan Bani Saad, 15 kilometres (nine miles) northeast of Baghdad, yet another parked car bomb exploded near a market and killed one civilian and injured nine others, they added.
Two Iraqi soldiers were killed in the town of Tarmiyah, 50 kilometres (30 miles) north of Baghdad, when their patrol hit a roadside bomb, another police officer and health official said. Six other people, including four civilians were wounded.
Health officials in Taji, Tarmiyah and Baghdad confirmed the casualties. All officials spoke anonymously as they were not authorized to release information.
Violence has dropped since the height of Iraq's bloodshed a few years ago, but Iraqi forces have failed to stop the attacks that continue to claim lives almost daily.
Senior central government officials were not available for comment.
Source: http://news.yahoo.com/bombs-target-shiite-areas-security-forces-multiple-cities-131016590.html
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Saturday, September 29, 2012
Concerns with contagion - STDs - MedHelp
Welcome to the forum.??Thanks for your questions.
2,3) I'm going first to these, because they contain the most important information you provide -- that you were immunized against hepatitis B virus (HBV) 6 years ago.??You can be very certain you are protected.??Although it is true that the vaccine isn't perfect, it is over 90% reliable -- probably close to 99%.??If you would like to confirm your immunity, you could be tested.??Having been immunized, a test for HBV antibody would probably be positive.??If so, you will know you are 100% protected.??In that case, you can safely have any and all sexual practices with your partner, without condoms for vaginal or anal sex.
1,4) Oral sex probably rarely transmits HBV, even with oral sores.??In the slight chance your immunization didn't work, condoms are highly protective.
Your last, unnumbered question also is important. Not all people with chronic HBV infection are highly infectious; and if your partner's hepatitis B surface antigen test (HBsAg) is only intermittently positive, it is likely her blood level of the virus is low and transmission risk might also be very low.??Also, she could have a test for hepatitis B e antigen (HBeAg); if that's negative, as it is in most chronically infected persons, then she is minimally infectious.
So here is my summary advice:??You and your partner should go together to the doctor or clinic where here HBV infection is managed.??You can have a test for HBV antibody to check whether you are protected from your immunization; and the doctor can also advise the two of you about sexual transmission risks.??Most likely you need not use condoms and can be confident you'll never catch HBV.
I hope this has helped.??Best wishes--??HHH, MD
Source: http://www.medhelp.org/posts/STDs/Concerns-with-contagion/show/1816244
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Friday, September 28, 2012
"Looper" Review: Stylish Time-Travel Tale That Loses Race With Clock
LOS ANGELES (TheWrap.com) - For a movie that's concerned with the passage of time, "Looper" allows the pacing to get painfully flaccid in its middle section. More's the pity, because the strong first act promises a smart and stylish movie about the vagaries of time travel.
While the stylish never goes away, the smart does, making this the second Rian Johnson movie in a row (following "The Brothers Bloom," the writer-director's sophomore effort after his Sundance hit debut "Brick") that looks great but meanders while doing it.
In a requisite grimy-city-of-the-future, Joe (Joseph Gordon-Levitt) is a "looper," which is a very specific kind of hit man. Decades beyond Joe's era, time travel will be discovered and immediately banned.
The only ones using it are mobsters, who dispose of their targets by sending them 30 years into the past so that Joe and other loopers can exterminate the unlucky saps and destroy the bodies.
When a looper "closes the loop," it means he kills his future self, collects a big payday and counts down the three decades until his own demise. Working for mobster Abe (Jeff Daniels, amusingly playing against type), Joe squirrels away his money and dreams of running off to France, even though Abe tells him the action is in China.
In a clever shout-out, Abe operates out of a nightclub called La Belle Aurore, named for the Paris bar where Rick and Ilsa hung out in "Casablanca" before the Nazis marched into town.
Naturally, Joe is eventually called upon to close the loop, but his older self (Bruce Willis) isn't going down without a fight. Future Joe met the woman of his dreams in Shanghai and watched her die before getting sent back in time, so he hopes to fix the future by changing the past.
All very well and good, and certainly the foundation for a fun little time-travel thriller -- and for the first third or so, that's what "Looper" is, from its stylish representation of the near future to the clever way Johnson lays out the exposition and the rules for the story. (Paul Dano's character finds out the hard way what Abe and his goons do to loopers who fail to close the loop.)
But by the time younger Joe hides out at the farm owned by Sara (Emily Blunt) to lie in wait for older Joe, the movie starts bogging down in circular storytelling and general meandering, leading to a viewing experience that feels awfully padded at two hours-plus. And none of this is helped by the idea of Emily Blunt as a woman who lives on a farm: That's the second-least convincing aspect of "Looper."
Number one is Gordon-Levitt's makeup job - rather than allow us to believe that the actor could simply age into becoming Bruce Willis, Johnson has decided to all but hide the "Inception" star under a thick layer of latex or CG effects or whatever it is that's going on with his face.
There's never that magic moment when, say, you stop thinking "That's Nicole Kidman with a fake nose" and instead decide, "That's Virginia Woolf."
From start to finish, Gordon-Levitt's face will make you think, "Why does he look like the love child of Kirk Cameron and Robert Forster?"
(Besides, it's not like we don't know what Bruce Willis actually looked like 30 years ago. Couldn't they just have put Gordon-Levitt into one of those white tuxes from the "Moonlighting" TV show and handed him a Seagram's wine cooler?)
By the time the inevitable time-travel paradoxes start kicking in - how could that be there if in the new reality this was no longer the other thing? - "Looper" has long since wasted its own potential.
When it eventually pops up on cable, you'll have the option of mastering time and space by watching the first 20 or 30 minutes and then turning it off forever.
There's never that magic moment when, say, you stop thinking "That's Nicole Kidman with a fake nose" and instead decide, "That's Virginia Woolf."
From start to finish, Gordon-Levitt's face will make you think, "Why does he look like the love child of Kirk Cameron and Robert Forster?"
(Besides, it's not like we don't know what Bruce Willis actually looked like 30 years ago. Couldn't they just have put Gordon-Levitt into one of those white tuxes from the "Moonlighting" TV show and handed him a Seagram's wine cooler?)
By the time the inevitable time-travel paradoxes start kicking in - how could that be there if in the new reality this was no longer the other thing? - "Looper" has long since wasted its own potential.
When it eventually pops up on cable, you'll have the option of mastering time and space by watching the first 20 or 30 minutes and then turning it off forever.
Source: http://news.yahoo.com/looper-review-stylish-time-travel-tale-loses-race-231638062.html
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Women on ballot in Palestinian city's first election in decades
AP
Palestinian Maysoun Qawasmi, the 43-year-old party leader of By Participating, We Can, attends a meeting in the West Bank city of Hebron on Sept. 13, 2012.
By Yara Borgal, NBC News
HEBRON, West Bank ? ?By Participating, We Can!? that slogan has made a group of women in Hebron who are challenging male dominance the talk of their famously conservative Palestinian city.
Hebron, the West Bank?s largest city with 250,000 Palestinian residents, will go to the polls to choose city officials for the first time since 1976 on Oct. 20. And it will be the first time that one of the candidate lists on the ballot is made up entirely of women ? teachers, civil-servants, business women and volunteers. ??
The road taken by these women has not, however, been easy.
They have faced tremendous opposition from the local community, including comments such as ?you are wasting your time.? ?
But Maysoun Qawasmi, leader of the bloc, and a 43-year-old mother of three sons and two daughters, remains undaunted.
Challenging the status quo
Qawasmi explained that the women initially faced legal objections to forming an all-female political bloc.
?I researched everything I could about election laws until I found out that there was no law against an all-female party competing,? Qawasmi said.?
She said some members of her own family initially resisted her challenging the status quo given the importance of tribal values woven throughout the fabric of society here.
For example, she explained that a local belief states, ?No matter where a woman reaches, her brain remains small.?
But Qawasmi, who wears a headscarf and describes herself as secular, has not lived by those words. She is a journalist and human rights activist. Politics are new to her, but she does not believe that her secularism puts her at any kind of political disadvantage.
?I go down and talk to people. I always tell my kids that social skills are more important than intellectual skills,? she said.
As a member of a prominent family clan in Hebron, her family name has been advantageous.
?We have a good CV and this is beneficial. But I am also up against five other candidates from the Qawasmi family. Besides, almost three quarters of my family clan support Hamas, so that?s at least 20,000 votes gone,? she said.
However, the Islamic group Hamas is boycotting this election because they fear being arrested by security forces from the Palestinian Authority or Israel if they campaign openly. So some experts think that could actually provide an opportunity for Qawasmi and her women?s bloc. ?
The idea of forming an all-female bloc stemmed from five years of work empowering women. For her and those around her, she had already crossed customary boundaries by becoming the manager of the Palestinian Wafa News Agency in Hebron.
The bloc had initially recruited 50 potential qualified candidates ? but that number whittled down to 11.
?Many high-caliber women had to pull out for various reasons,? she said. ?We had a highly qualified woman with a Ph.D. who had to pull out when a brother chose to run for elections in the same family; the male is given priority over the woman.?
Generally, running as a bloc increases the chances of getting more votes leading to a higher number of seats in the municipality. Qawasmi believes that her bloc is likely to gain support from young men and women.
?Women should represent society, but not to this extent?
Not everyone however, agrees with her vision.
Wadie, a 35-year-old chef from Hebron, offered his opinion on the matter.
?Our religion does not give a woman the right to enter the Shura Council (Consultative Council). It dignifies her to be in her house,? said Wadie, only chose to share his first name.
?I personally don?t believe she will get votes except from the Qawasmi family. If Qawasmi succeeds she will be fought against, she is not liked because she encourages freedom.?
He added a religious argument to his opposition. ?Eighty percent of Hebron is religious?I have to stick to the book of God. Women should represent society, but not to this extent.?
Wadie?s opinion may represent a high percentage of the men in Hebron, but there are others who are looking at more than gender with their vote.?
?It?s not a man or woman thing, people judge according to who works harder. If the rest of the bloc was as strong as [Qawasmi] they would have a chance at winning,? said Issa Amr, a 33-year-old male resident of Hebron.
Hoping other women will follow
For now, Qawasmi is satisfied that the bloc has been officially registered.
?I want to do what I can do. I want to do what must be done by decision makers and prioritize real issues that have not been addressed by the municipality,? she said. ?I hope this will enhance the role of women in the political sphere at the larger level. I do expect women in other locations to follow.? ??
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Thursday, September 27, 2012
Author Turns Filmmaker to Widen Warning on 'Death by China ...
Peter Navarro has written numerous books on economic policy that have brought him considerable status as a commentator, particularly on foreign trade issues.
Still, when you're a man on a mission, you don't get far by preaching to choirs.
So Navarro, a professor of economics and public policy, became a film director.
"I've learned that writing policy books, even when they sell well by industry standards, don't reach that many people," Navarro said in an interview Wednesday.
"What happened with 'Inconvenient Truth' taught me that the way to get through to a lot of people is through film."
Navarro will appear in person Thursday night at the Rosebud Cinema Drafthouse to introduce his first feature documentary, "Death by China," and to moderate a discussion to follow.
The movie is based on his book, fully titled "Death by China: Confronting the Dragon ? A Global Call to Action."
A pre-election call to action
Navarro's visit and the screenings of his film ? it will show at the Rosebud on Saturday and Sunday as well ? are part of a tour through political swing states to call attention to "the most urgent problem facing our country," Navarro said.
Navarro arrived in Milwaukee Wednesday morning by ferry from Michigan, after showings and town hall talks there and in politically critical Ohio.
"I'll be visiting most of the swing states," he said, "and starting with the manufacturing states, trying to call attention to the need to crack down on unfair trade practices."
"It's been really interesting to see the resources here, the manufacturing base that still exists but is lying fallow," Navarro said. "I believe that cities like Milwaukee, Cleveland and Detroit can be the center of America again. Everything's here. The only thing we have lost is our competitive edge ? because China is allowed to cheat."
"There are three people, or entities, who can solve this problem," Navarro said. "Two are the candidates running for president of the United States.
"But the candidates have given us nothing but platitudes. They talk about creating jobs but not about what has cost us jobs."
A line in the movie, he said, speaks volumes to the political issue: "Both parties have failed us in the same way."
"On the Republican side, we have to cut spending. The Democrats want to raise taxes. But they're both just fighting over a shrinking pie.
"If we simply had two points more in GDP (gross domestic product) growth, we wouldn't have to worry about deficits."
'We can compete,' but we must believe it
The third party that can influence a future for American manufacturing, Navarro said, is "you and I and everybody buying manufactured goods. We have to demand a stop to the human rights abuses, the environmental abuses, a stop to the stealing of our technology ? and for our corporate leaders to stop giving it to them.
"What we have to understand is that we can compete. China has the highest-cost steel manufacturing processes in the world ? and sells it the cheapest. You only do that through subsidies ? subsidies paid every day on every order they ship."
To those who say that American companies, to compete at all, must outsource and offshore jobs to low-cost labor markets, Navarro has a answer.
"Let's find out. It's the $3 trillion question, isn't it, because that's what our China trade deficit is now."
"So we shouldn't crack down on unfair trade practices because we can't compete anyway? The way to beat cheap labor practices is to be more productive.
"Another line from the movie that stands out for me is what Chris Street says: 'We're not going to regain our place in the world by exporting. We're going to do it by regaining our market.'"
________________________________
'Death by China' at the Rosebud
Thursday: Special director's screening with a brief introduction by Peter Navarro at 6:45 p.m. (run time 78 minutes), followed by a Town Hall discussion led by Navarro.
Saturday and Sunday: Film at noon
Admission: $7
Location: Rosebud Cinema Drafthouse, 6823 W. North Ave.
_____________________________
Peter Navarro
Author and director Peter Navarro is a professor at the Paul Merage School of Business at the University of California, Irvine. He holds a Ph.D. in economics from Harvard University.
Navarro is a regular contributor on CNBC and appears frequently on Bloomberg TV and radio, CNN, NPR, Marketplace and major network news shows.
Source: http://wauwatosa.patch.com/articles/author-turns-filmmaker-to-widen-warning-on-death-by-china
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Section 481 Tax Relief; the future of film relief
Posted on 27th September 2012
The Section 481 tax relief, more commonly known as ?film relief?, is one of Ireland?s longest running sector-specific tax reliefs and has been in place under various formats since 1984.
Created to help promote Ireland as a location for film production, the relief enables production companies to raise finance in Ireland and incentivises individual taxpayers to invest by offering an attractive return on a relatively low risk investment.
The relief has become steadily more and more popular in recent years as production companies and taxpayers alike begin to realise and appreciate the attractiveness of the relief. In 2005, for example, just 19 projects availed of the Section 481 relief compared with 57 in 2011.
There is no doubt that the film industry exists in a competitive international environment. Ireland competes with other countries and locations for productions and although other countries may also support their film industry by way of tax reliefs we must always look objectively at the cost versus benefit of any tax relief that is legislated for.
The estimated amount of tax foregone by the exchequer in respect of film relief in the 2011 tax year was ?49 million. According to the Revenue Commissioners the 57 projects that were approved for Section 481 funding in 2011 had an eligible Irish spend of ?114 million and supported employment for a crew, cast and extras of over 15,000 individuals.
In a welcome move, Finance Act 2011 provided for an extension of film relief to the end of 2015, however, given the current pressures on the exchequer the Government has deemed it necessary to carry out a formal consultation on the economic merits of continuing the relief after 2015. Among the questions that will be asked in regard to the relief are:
a) Is the exchequer?s support to the film and TV sector in Ireland through Section 481 tax relief an efficient use of scarce resources?
b) Is the current scheme maximising the potential economic benefits to Ireland in terms of stimulating activity in the film and TV sector?
c) Does the scheme provide value for money to the economy overall?
There are arguments aplenty for and against each of the questions. However, something which supports a significant number of jobs and boosts the tourism sector, can only be a good thing in our eyes. Whether or not it will last beyond 2015, however, remains to be seen.
Source: http://blog.taxback.com/government-zooms-film-relief
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Prominent Kremlin critic faces criminal charges
MOSCOW (AP) ? Russia's top investigative agency says it has filed criminal charges against a Russian tycoon whose holdings include a newspaper critical of the Kremlin.
The State Investigative Committee said Wednesday that it charged Alexander Lebedev with hooliganism and assault over a TV shown incident in which he punched another businessman.
Alexander Lebedev, whose net worth was reported by Forbes magazine to be $1.1 billion, made his money in the banking industry and owns a stake in Russian flag carrier Aeroflot as well as his own Red Wings airline. He has financed Novaya Gazeta, which is fiercely critical of the Kremlin, and two British newspapers ? the Independent and the Evening Standard.
Lebedev said last month that he was forced to sell his assets because of pressure by the Russian security agency.
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Wednesday, September 26, 2012
CAW chief says Chrysler contract deal possible today
TORONTO (Reuters) - Canada's autoworkers could seal a new labor agreement with Chrysler Group LLC on Wednesday night, union president Ken Lewenza said, in a huge shift in the tone of drawn-out, challenging negotiations.
Fiat SpA's Chrysler, the last of the Detroit Three automakers without a new contract, submitted a written proposal on Tuesday night that reignited the difficult talks, said Lewenza, who is the national president of the Canadian Autoworkers union (CAW).
"I absolutely think it's possible," to reach a deal on Wednesday, Lewenza told Reuters after a morning meeting with the CAW's Chrysler negotiating team. "There's still some very, very minor issues around the pattern that have to be dealt with. We're going to keep working at it over the course of the day."
Ford Motor Co workers ratified their deal at the weekend, while General Motors Co employees vote on Wednesday and Thursday.
Chrysler, which has more than 8,000 unionized workers in Canada, declined to comment on the negotiations.
Lewenza declined to say how the two sides would resolve a Chrysler demand to eliminate a cost of living increase and adjust lump sum payments that form key elements in the deals with Ford and GM.
"It's too sensitive right now," Lewenza said. "The fact of the matter is one little miscommunication could stop the momentum and I'm not prepared to do that."
Lewenza will be in Oshawa, Ontario, as CAW workers vote on their deal with GM, but he said he will stay in touch with Chrysler throughout the day and meet with the company in Toronto at 6:30 p.m. (2230 GMT) on Wednesday.
The CAW reached an agreement with Ford on September 17, and used that deal to set the pattern for deals with GM and Chrysler in an effort to ensure that no company has a labor cost advantage over its rivals.
Chrysler argued that, as the smallest and most vulnerable of the Detroit Three, it could not afford Ford's framework deal and needed to eliminate any increase in fixed costs, Lewenza has said. It also wanted flexibility on the timing and structure of lump sum bonus payments that total C$9,000 ($9,100), including a C$3,000 ratification bonus.
The CAW, which represents more than 20,000 workers at the Canadian plants of the three automakers, has a deal with Ford and GM that freezes wages until June 2016, when a cost of living increase will be introduced.
The agreement also starts new workers at 60 percent of the highest hourly rate of C$33.85, down from 70 percent in the last contract. It will take 10 years to reach the top of the pay scale, up from six years.
The CAW insisted that new employees eventually reach the top pay scale, in contrast to their U.S. counterparts at the United Auto Workers, who have a permanent two-tier wage structure.
New employees will also contribute more money to a pension plan that mixes elements of a defined benefit and defined contribution plan. A defined contribution plan for current employees is unchanged.
($1=0.98 Canadian)
(Reporting By Susan Taylor; Editing by Peter Galloway and Janet Guttsman)
Source: http://news.yahoo.com/caw-president-says-possible-reach-deal-chrysler-today-132330719--finance.html
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Tuesday, September 25, 2012
Siegel Solutions, Inc. Selected as Premier Intuit Reseller - Business ...
LEXINGTON, Mass., Sept. 24, 2012 /PRNewswire-iReach/ --?Siegel Solutions, Inc. announced today that it has been?selected as?an?Intuit? Premier Level Reseller Program Member. Siegel Solutions offers a full range of value-added?consulting services for Intuit business and financial management solutions. Intuit Inc., the maker of QuickBooks?, is the leading provider of business and financial management solutions for small and mid-sized businesses, consumers and accounting professionals.?
The Intuit Premier Reseller level is the highest achievement in the Intuit Reseller Program. The Premier Reseller Program will enable Siegel Solutions to better serve local small and mid-market businesses through the sale, implementation and service of Intuit solutions that help businesses save and make money.
The Intuit solutions that Siegel Solutions will support include QuickBooks Enterprise, QuickBooks Point of Sale and related solutions including Intuit Payroll and Intuit Payment solutions. Additionally, Siegel Solutions will support various 3rd party add-ons to QuickBooks such as Salesforce, Results CRM, WebKPI and others.
"Intuit Premier Reseller membership is an elite program earned by firms with a proven track record of sales, marketing, and service execution that best meets the needs of small and mid-market customers," said Simon Pass, sales leader of the Intuit Solution Provider Channel. "We are very excited to have Siegel Solutions as an Intuit Premier Reseller Member supporting customers in their area."
"With over 10 years of helping business setup, integrate and better use their accounting systems, as well as provide outsourced bookkeeping to hundreds of small to medium sized businesses, we have grown to count on Intuit's accounting products", said Jeffrey Siegel CPA, President of Siegel Solutions. "Along with the quality products that we can count on, the Intuit Premier Reseller Program offers an extensive range of business solutions that will help us better serve our existing customers and acquire new ones."
About Siegel Solutions Inc.
Siegel?Solutions is a provider of onsite as well as cloud-based bookkeeping services to small and mid-sized businesses. Other accounting services provided consist of controllership, training, setup, workflow creation, bill payment, budget creation and custom reporting.?Siegel Solutions also resells?QuickBooks?products including Point of Sale and?QuickBooks?Enterprise and with these sales provides additional services such as conversions, installation, implementation, training and?3rd?party program integration. Founded in 2000, Siegel Solutions has 12 employees and has offices in Lexington, MA and Nashua, NH<o:p></o:p>
About Intuit Inc.
Intuit Inc. is a leading provider of business and financial management solutions for small and mid-sized businesses; financial institutions, including banks and credit unions; consumers and accounting professionals. Its flagship products and services, including QuickBooks?, Quicken? and TurboTax?, simplify small business management and payroll processing, personal finance, and tax preparation and filing. ProSeries? and Lacerte? are Intuit's leading tax preparation offerings for professional accountants. The company's financial institutions division, anchored by Digital Insight, provides on-demand banking services to help banks and credit unions serve businesses and consumers with innovative solutions.
Founded in 1983, Intuit had annual revenue of $3.2 billion in its fiscal year 2009. The company has approximately 7,800 employees with major offices in the United States, Canada, the United Kingdom, India and other locations. More information can be found at www.intuit.com.
All products mentioned in this release are trademarks or registered trademarks of their respective holders.
Media Contact: Jeffrey Siegel, Siegel Solutions, Inc., 781-487-7000, jeff@siegelsolutions.com
News distributed by PR Newswire iReach: https://ireach.prnewswire.com
SOURCE Intuit Inc.
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Einstein's brain is now interactive iPad app
This digitized image made from a screen shot of a new iPad app, provided Sept. 24, 2012 by the National Museum of Health and Medicine Chicago, shows an image of brain tissue from renowned theoretical physicist Albert Einstein. The new application to be released Tuesday, Sept. 25 will allow users to see Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Courtesy the National Museum of Health and Medicine Chicago)
This digitized image made from a screen shot of a new iPad app, provided Sept. 24, 2012 by the National Museum of Health and Medicine Chicago, shows an image of brain tissue from renowned theoretical physicist Albert Einstein. The new application to be released Tuesday, Sept. 25 will allow users to see Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Courtesy the National Museum of Health and Medicine Chicago)
In this Monday, Sept. 24, 2012 photo, Dr. Phillip Epstein, left, and Steve Landers of the National Museum of Health and Medicine Chicago talk about the new iPad app being released Tuesday, Sept. 25 that allows users to see Albert Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Carla K. Johnson)
This digitized image taken from a screen shot of a new iPad app, provided Sept. 24, 2012 by the National Museum of Health and Medicine Chicago, shows an image of a portion of the brainstem of renowned theoretical physicist Albert Einstein. The new application to be released Tuesday, Sept. 25 will allow users to see Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/The National Museum of Health and Medicine Chicago)
In this Monday, Sept. 24, 2012 photo, Dr. Phillip Epstein, left, and Steve Landers of the National Museum of Health and Medicine Chicago talk about the new iPad app being released Tuesday, Sept. 25 that allows users to see Albert Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Carla K. Johnson)
CHICAGO (AP) ? The brain that revolutionized physics now can be downloaded as an app for $9.99. But it won't help you win at Angry Birds.
While Albert Einstein's genius isn't included, an exclusive iPad application launched Tuesday promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look.
A medical museum under development in Chicago obtained funding to scan and digitize nearly 350 fragile and priceless slides made from slices of Einstein's brain after his death in 1955. The application will allow researchers and novices to peer into the eccentric Nobel winner's brain as if they were looking through a microscope.
"I can't wait to find out what they'll discover," said Steve Landers, a consultant for the National Museum of Health and Medicine Chicago who designed the app. "I'd like to think Einstein would have been excited."
After Einstein died, a pathologist named Thomas Harvey performed an autopsy, removing the great man's brain in hopes that future researchers could discover the secrets behind his genius.
Harvey gave samples to researchers and collaborated on a 1999 study published in the Lancet. That study showed a region of Einstein's brain ? the parietal lobe ? was 15 percent wider than normal. The parietal lobe is important to the understanding of math, language and spatial relationships.
The new iPad app may allow researchers to dig even deeper by looking for brain regions where the neurons are more densely connected than normal, said Dr. Phillip Epstein, a Chicago-area neuroscientist and consultant for the museum.
But because the tissue was preserved before modern imaging technology, it may be difficult for scientists to figure out exactly where in Einstein's brain each slide originated. Although the new app organizes the slides into general brain regions, it doesn't map them with precision to an anatomical model.
"They didn't have MRI. We don't have a three-dimensional model of the brain of Einstein, so we don't know where the samples were taken from," said researcher Jacopo Annese of the Brain Observatory at the University of California, San Diego. What's more, the 1-inch-by-3-inch Einstein slides on the app represent only a fraction of the entire brain, Annese said.
Annese has preserved and digitized another famous brain, that of Henry Molaison, who died in 2008 after living for decades with profound amnesia. Known as "H.M." in scientific studies, Molaison participated during his life in research that revealed new insights on learning and memory.
A searchable website with images of more than 2,400 slides of Molaison's entire brain will be available to the public in December, Annese said.
"There will be another Einstein and we'll do it like H.M.," Annese predicted. For now, he said, it's exciting that the Einstein brain tissue has been preserved digitally before the slides deteriorate or become damaged. The app will spark interest in the field of brain research, just because it's Einstein, he said.
"It's a beautiful collection to have opened up to the public," Annese said.
Some may question whether Einstein would have wanted images of his remains sold to non-scientists for $9.99.
"There's been a lot of debate over what Einstein's intentions were," museum board member Jim Paglia said. "We know he didn't want a circus made of his remains. But he understood the value to research and science to study his brain, and we think we've addressed that in a respectful manner."
Paglia said the app could "inspire a whole new generation of neuroscientists."
Proceeds from sales will go to the U.S. Department of Defense's National Museum of Health and Medicine in Silver Spring, Md., and to the Chicago satellite museum, which is set to open in 2015 with interactive exhibits and the museum's digital collections.
___
AP Medical Writer Carla K. Johnson can be reached at http://www.twitter.com/CarlaKJohnson .
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Monday, September 24, 2012
Packers Hall of Famer Will Henderson opens frozen yogurt shops ...
Posted on: 8:21 pm, September 23, 2012, by Tom Pipines, updated on: 09:15pm, September 23, 2012
WHITEFISH BAY ? Green Bay Packers Hall of Famer, number 33 William Henderson is now the owner of the Sweet Frog frozen yogurt shop.
?This organization started back in Virginia several years ago. It started on the concept that we want to bring families together, and think of charity ? how we can bring charity to the community. With a great option, and a great healthy choice, but then we can benefit other programs in the meantime,? Henderson said.
One of Will Henderson?s friends in Virginia came up with the Sweet Frog concept. He and his wife then called former Green Bay Packers? fullback Henderson.
?They asked me to bring this wonderful concept to a state I have fallen in love with. The opportunity to bring it to Wisconsin was immediate for me, and was an immediate ?yes.? That is what I have been doing the entire time I have been with the Green Bay Packers ? trying to find out ways to thank and contribute to the people who have been so gracious and supportive,? Henderson said.
The Sweet Frog frozen yogurt business certainly benefits from having Henderson on its side.
?He?s an amazing business man, and he?s very talented, on and off the field. As a person, he?s just so humble,? Sweet Frog Regional Director Michael Garrison said.
Henderson never missed the chance to throw a bone-crushing block, and he doesn?t plan on being an absentee owner. Henderson believes in his product and its benefits.
?We?re not trying to deny everybody of their frozen custard or their ice creams or whatever that stuff they serve at McDonald?s is. I?m not being mean, but this is actually yogurt. This is a healthy, high-protein supplement for your diet,? Henderson said.
The challenge is controlling portions, and staying away from the gummy worms! Packers? greats Ahman Green and Jerry Kramer managed to do that when they stopped by during the recent grand opening to offer their support.
?That is really special. We work so hard up there to do things right, and create an image in society and in the state, and to see a young guy like William come along who is not only a really good football player and the guy who sacrificed himself the most of the time for other people, and to see him succeed as a businessman, that?s very gratifying,? Kramer said.
?Because of my history and my ties to the green and gold team just down the road, I get to hopefully address the need and desire to keep the Packers as America?s team. When you come in and see myself or some of my former teammates, or even my mentors from the 60s like Jerry Kramer ? if you see any of those guys at the location, we?re hopefully encouraging the next generation of Packers fans,? Henderson said.
Henderson?s Wisconsin Sweet Frog franchises are located in Plover and Whitefish Bay. Shops are coming soon to Brookfield and De Pere.
Source: http://fox6now.com/2012/09/23/packers-hall-of-famer-will-henderson-opens-frozen-yogurt-shops/
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New York Times closes on $300M sale of About Group
NEW YORK (AP) ? The New York Times has completed its $300 million sale of The About Group to Barry Diller's IAC/InterActiveCorp.
IAC, which operates online businesses including Newsweek, The Daily Beast and dating site Match.com, announced the deal last month.
About.com provides information on a wide variety of topics and also operates ConsumerSearch.com and Calorie-Count.com. The site's content is written by paid experts known as guides.
The New York Times said Monday that it anticipates receiving about $290 million from the sale and plans to use those funds for general corporate purposes.
IAC says The About Group will become part of its search and applications segment.
The New York Times Co. purchased About.com in 2005 for roughly $410 million. About.com has suffered in the past year because of a change in the way Google handles search results. The change made About.com content difficult to find.
The New York Times Co.'s stock added 6 cents to $9.64 in midday trading, while IAC/InterActiveCorp's stock fell 71 cents to $52.51.
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Sunday, September 23, 2012
thejoshuablog: RT @ppppolls: Romney's net favorability in Florida has dropped 9 points in the last three weeks
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Closing Cost Estimator ? Saving Money On Closing Costs - No ...
Most home buyers, especially new ones are not aware of their liability to additional costs when purchasing real estate property. In order to enjoy a smooth experience when purchasing real estate property, it would be a good idea to have some extra cash stashed away just in case. The extra cost incurred may be due to factors such as lawyer fees, your negotiation skills, several third party fees and lenders. To get a good estimate on your property?s closing cost, you will need to use a closing cost estimator. This article provides information on closing estimation and how you can save thousands during real estate purchases.
Here are some fees to expect during real estate transactions; Attorney fees, title insurance, loan discount points, loan original fees, property taxes, recording fees and premium for mortgage insurance among others. Depending on where you are coming from and the companies you are working with, the amount to be paid will vary.
To make your work easier, it would be best to know the fees that are negotiable and those that are not. Fees such as those from recording fees, prorate interests, taxes and city stamps will have to be paid. However, fees from appraisal, loan-processing fees, third-party fees and lender charges can be negotiated, reducing the amount of money spent on closing cost.
How Can You Lower Closing Costs?
Attorney fees ? Attorneys are very important when it comes to closing a real estate deal. They will help you deal with all the legalities associated with real estate transactions, making your work easier. Fair charges from attorneys range between $500 and $800. A good way to negotiate this amount is by simply asking the lawyers to charge by the hour. By doing this, you will have several fees charged together, saving a good amount of money on the services.
Lender fees ? Not all lenders charge these fees. In fact, most of these charges are mostly found in services offered by small banks and mortgage brokers. The cost may be incurred through preparation of documents, application fees and determination of interests charged. Eliminating some of these elements can see you save thousands of dollars in closing cost. It will be uip to you to decide the services you need and those that you want to get rid of.
Recording fees and property taxes are a bit harder to escape but with the right knowledge, you can see yourself reduce the amount paid for the process. The amount paid on recording fees and property taxes is usually about a 3rd of the property cost. This cost is usually shared between the seller and the buyer.
Title insurance ? Owner?s and loan policies are the only two types of title insurance policies there are. The amount paid on loan title insurance is based upon the loan amount while owner?s policy will be based upon the real estate property?s purchase price.
There are many different websites offering closing cost estimator software. This allows new real estate investors determine the amount of money they will be able to save during a transaction.
Source: http://www.zeroclosingcostmortgage.com/closing-cost-estimator-saving-money-on-closing-costs.php
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Saturday, September 22, 2012
Court rules Wal-Mart can fire legal medical marijuana user | The ...
Although he lives in a state where medical marijuana is legal, a federal court ruled on Wednesday that a Michigan man could be terminated by his employer for testing positive for the drug.
Doctors diagnosed Joseph Casias with sinus cancer and an inoperable brain tumor at the age of 17. After Michigan legalized the use of medical marijuana in 2008, Casias?s oncologist recommended that he try the drug marijuana to relieve both his pain and the side effects of other prescribed pain medications.
Casias used marijuana during the final months of his five-year employment at a Wal-Mart in Battle Creek, Michigan. Although the drug proved beneficial, Casias made certain never to use it on the job or come to work under the influence.
However, after Casias was injured on the job in Nov. 2009, Wal-Mart company policy required he be administered a drug test as a routine measure.
Unsurprisingly, Casias tested positive for marijuana. Wal-Mart fired him a week later.
Casias, represented by the ACLU, sued Wal-Mart for wrongful discharge and violation of Michigan?s Medical Marihuana Act, arguing that the law prohibits a business from sanctioning a patient legally using the drug.
The U.S. District Court for the Western District of Michigan ruled that Wal-Mart did not violate Michigan law by firing Casias. On Wednesday, a three-judge panel of the U.S. Sixth Circuit Court of Appeals agreed.
In a split 2-1 ruling against Casias, the court focused on the following portion of Michigan?s medical marijuana law:? ?A qualifying patient ? shall not be subject to arrest or ? disciplinary action by a business or occupational or professional licensing board or bureau ??
Casias and his attorneys argued that the law prohibits ?disciplinary action by a business? against a patient using legal medical marijuana.
Ezekiel Edwards, director of the ACLU?s Criminal Law Reform Project, explained Casias? argument to The Daily Caller News Foundation.
?We paid attention to the fact that there?s a disjunctive separating ?business? from the words that follow it, ?occupational or professional,?? he said.
Edwards provided the DCNF a copy of the ACLU?s brief, which further explained, ?the use of ?or? instead of a comma between ?business? and ?occupational? signifies that ?business? is to be read independently from ?occupational or professional licensing board or bureau.??
The court, however, read the statute differently and ruled against Casias on a different interpretation of the grammar.
It found that the statute is referring to a series of three types of licensing boards and bureaus ? business, occupational, and professional.
Accordingly, the court reasoned that the statute merely prohibited disciplinary action from different varieties of licensing boards and not a private business.
Since it saw no legal protection against termination in the statute, the court found no reason to dispute Wal-Mart?s firing of Casias. However, the court stated that the law does protect Michigan citizens from criminal prosecution.
Edwards criticized this narrow interpretation of Michigan law, telling the DNCF, ?We don?t feel that the court really addressed in a particularly detailed and analytic way the wording of the statute.?
He also accused the court of undercutting the Michigan legislature, explaining,? ?It obviously would seem to undermine the intent of passing the Michigan Medical Marihuana Act that allows sick patients with debilitating or painful conditions to access the medicine but then somehow not protect them from this kind of severe disciplinary action from an employer.?
Absent an agreement by either the entire Sixth Circuit or the U.S. Supreme Court to hear an appeal, Wednesday?s ruling will be final.
Edwards would not confirm whether Casias and the ACLU would try to appeal the case, but he did indicate they ?are seriously considering that option.?
Edwards also suggested there might be a legislative solution. He sees this as ?an invitation to the Michigan legislature [and] Michigan citizens to enact legislation? that is ?more explicit in protecting medical marijuana patients? so ?they don?t have to make a choice between gainful employment, paying their rent, and their career ? and treating symptoms of debilitating diseases.?
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Source: http://dailycaller.com/2012/09/20/court-rules-wal-mart-can-fire-legal-medical-marijuana-user/
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Friday, September 21, 2012
How To Laser Target Your Prospects With Facebook Ads | The Daily ...
- The Daily Egg
- How To Laser Target Your Prospects With Facebook Ads
by Adam Kreitman 09/20/2012 It?s popular to trash Facebook these days.
Its stock price has fallen to record lows, billionaires are dumping their stock, big companies are abandoning their paid advertising campaigns and there have even been doubts raised about the legitimacy of Likes companies get from their FB ads.
Certainly Facebook advertising isn?t going to work for everyone. As I wrote about a few months back, it?s very difficult to get direct sales from Facebook ads. But, depending on the kind of business you?re in and your strategy, FB ads can and do work.
What Facebook has going for it that no other company can match is an incredibly rich amount of demographic data about their users. From the information you put in your profile to your Likes to the web pages you visit, Facebook has compiled the most accurate and complete demographic profiling information available to most advertisers.
So, let?s focus on the positive here!
In this article we?re going to look at how demographic targeting on Facebook works and three real world examples to see how different businesses can use Facebook to laser target their prospects.
How To Target Your Prospects on Facebook
When trying to reach your target demographic on Facebook, there are a number of the usual options you?d expect?Age, Gender, Education, Location (Country, State, City, Zip Code), etc.
And while that?s all well and good, where things really get interesting is in the more advanced demographic and interest targeting options. Here you can target people by their likes and interests either through Broad Category Targeting or Precise Interest Targeting.
Broad Category Targeting
With Broad Category Targeting, you check off pre-set groups from a list of categories Facebook has compiled. Here are some of examples of the groups you can target within these broad categories:
- Activities: Cooking, Gaming(Social/Online), Gardening, Photography
- Family Status: Away From Home, Baby Boomers, Engaged, Expecting Parents, Parents (child: 4-12yrs)
- Interests: Charity/Causes, Health & Well-being, Home & Garden, Pets (Cats), Pets (Dogs), Politics (US Non-Partisans)
- Retail/Shopping: Beauty Products, Consumer Electronics, Fashion, Luxury Goods
Precise Interest Targeting
With Precise Interest Targeting, you type in keywords and Facebook will come up with a list of related likes and interests you can use to target prospects. Here?s an example where I type in the keyword ?entrepreneur??
With Precise Interest Targeting, you can type anything from names of brands, movies, books and TV shows to activities such as home schooling, baseball and crocheting to occupations/job titles such as lawyers, engineers, CEOs. And much more!
To get a better sense of how this all targeting can work, let?s look at some real world examples.
I?ve picked out 2 real businesses and 1 ?generic? politician (to keep things non-partisan!) and have come up with suggestions of different targeting options they could use to reach prospects through Facebook ads. (Note: None of these are clients of mine and I have no connection to, or insider knowledge of, their businesses).
Example 1 ? ikram Clothing Store
ikram is a high end women?s clothing store in Chicago.
When targeting an affluent, fashion conscious market the easiest way to do so on Facebook Ads is through the Broad category options of ?Fashion? and ?Luxury Goods?.
If we were to target Facebook users who fall in those categories and live within 10 miles of Chicago, we get an audience of 1,041,400 people. That?s a pretty big group and it?s often better to more finely slice and dice things for optimal results.
One way to do that is to limit your demographics by age and gender. Since ikram sells women?s clothing, it makes sense to target women with their ads (though they could run ads to men promoting ikram as a place to get memorable, unique gifts for spouses or girlfriends).
ikram could also narrow the age range to target women 35 and older (who are likely to have more disposable income).
Another trick I?ve used in campaigns targeting more affluent customers is to set the Education targeting option to ?College Grad.? By targeting college grads (as with targeting an older demographic), you tend to reach a more affluent group.
Instead of targeting the Broad Interest categories of Fashion and Luxury Goods, ikram could also switch to Precise Interest Targeting and use keywords that their customer base likes.
For example, they could target?
- Larger, high end fashion stores like Nordstrom, Saks Fifth Avenue, and Neiman Marcus
- High end fashion brands like Louis Vuitton, Giorgio Armani and Coco Chanel
- High end brands (not necessarily related to fashion) like BMW, Lexus and Lancome.
While ikram can certainly target Facebook users across Chicago, having some campaigns that target users in more affluent cities like Naperville, Highland Park or Lake Forest could work well.
Also, there are affluent neighborhoods within the city of Chicago that can?t be targeted by city name. By using zip code targeting, however, ikram could run ads in these neighborhoods. (You can only target ads by city OR zip code so, in this case, you?d have to set up one ad that targets the suburbs and another that targets within the city limits of Chicago by zip.)
Lastly, Facebook lets advertisers target users on or around their birthday. Using this information, ikram could run ads promoting a special 25% Off birthday coupon that will reach people right around their birthdays.
Example 2 ? Generic Political Candidate
It?s campaign season here in the U.S. You can?t turn on the TV without seeing ads for politicians. Political yard signs are sprouting up like weeds. And the backs of cars are getting covered up with bumper stickers for, or against, various candidates.
But how could a candidate turn to Facebook to reach voters?
I won?t use any specific politician here as an example, but let?s look at some of the ways a politician, in general, could use Facebook advertising.
First, and most obvious, is targeting users geographically. Depending on whether the candidate is running for local, state or national office, they could use Facebook?s geographic targeting options to reach their intended audience.
Also, since you have to be 18 or older to vote, it makes sense to run ads only to those 18 and above.
But politicians can get very creative using Facebook.
Sticking with age targeting for a moment. The candidate may want to target older voters with ads promoting the politician?s plans for Social Security and Medicare. There are over 16 million FB users who are 64 or older in the United States that could be targeted with ads about those issues.
Let?s say you have a candidate that wants to tout their strong record of protecting the environment. Under ?Interests? in the Broad Category targeting, one of the options is ?Environment? which the candidate could easily use to target voters who are likely to care more about environmental policies.
Using Precise Interest Targeting, the campaign could get even more creative. They could target:
- Users who like the Sierra Club, the National Wildlife Federation and other environmental groups.
- People who like Al Gore and/or his movie ?The Inconvenient Truth?.
- Those who enjoy outdoor activities like fishing, hiking, or hunting.
Facebook also lets you target parents. So a political candidate could run ads touting their plans for Education to parents (and you can get specific on Facebook here by targeting parents of kids of various ages as seen below).
There?s also an ?Education/Teaching? option under the Broad category of ?Interests? that could be useful here.
This is just the tip of the iceberg for a politician. They can target people by political affiliations, specific political causes, and more. A savvy political campaign could get very strategic on Facebook by targeting highly relevant ads to specific demographic groups.
Example 3 -? Chobani Greek Yogurt
For our last example, let?s look at Chobani, a national brand of Greek Yogurt.
For starters, Chobani has a product line, Chobani Champions, made just for kids. To target parents of kids with this healthy snack idea, here are a few options?
Since moms tend to do more of the food shopping, they could limit their ads to just target women. Then, as with our political candidate example, Chobani could benefit from targeting Parents using the Broad Interest Targeting options on Facebook. If their primary target market here is young kids to teens, they could limit ads serving to only Parents (child: 4-12) and Parents (child: 13-15).
Using Precise Interest Targeting, Chobani could focus on brand names and interests that parents identify with.
One option is to use brand names like Graco (baby products), Fisher-Price and/or Build-A-Bear Workshop.
They could also target specific groups such as Soccer Moms, Homeschoolers, or Mommy Bloggers (the last is not a big group, but the hope would be to get some Mommy Bloggers talking about Chobani on their blogs for the viral marketing effect).
Another market for Chobani is adults looking for a healthy snack/meal.
There are some Broad Interest category groups worth testing that would target Facebook users more likely to be interested in healthy products/snacks. Two good options here are ?Outdoor Fitness Activities? (under Activities) and ?Health & Wellbeing? (under Interests).
For Precise Interest Targeting, Chobani could target specific activities enjoyed by those interested in a healthy lifestyle such as yoga or those who participate in marathons or triathlons.
Since Chobani sells Greek Yogurt, obviously targeting those who Like Greek Yogurt makes sense! This can be done by targeting the keyword ?Greek Yogurt? as well as by targeting the names competing brands like Voskos and Oikos.
Another interesting opportunity for Chobani that I?ve successfully used in the past is targeting people interested in Couponing with ads promoting a coupon.
There are a number of coupon websites that get a ton of traffic and have very loyal followers. If one of those sites picks up on a coupon Chobani offers through Facebook, the coupon could easily go viral and reach many more people who would not have seen the Facebook ads. (Using this strategy, the brand I was running FB ads for got thousands of Likes in a few days because a few coupon sites published their coupon?and they only spent about $50 in clicks during that time!)
These three examples give you a taste of what?s possible with Facebook targeting. As you can see, you can get very creative in how you reach your ideal prospects.
Yes, it can be a challenge to measure the results of FB ads. Yes, it?s difficult to convert Facebook visitors into customers. And, yes, there?s a lot of room for improvement for FB paid advertising.
But, if you know who you?re trying to reach, you can get very targeted, and very creative, about reaching them through Facebook.
About the Author:? Adam Kreitman is an?internet marketing consultant?who owns Words That Click, a?firm focusing on online marketing strategies for small and mid-size businesses.
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Source: http://blog.crazyegg.com/2012/09/20/target-prospects-with-facebook-ads/
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Informatics approach helps doctors, patients make sense of genome data
ScienceDaily (Sep. 20, 2012) ? The cost of sequencing the entire human genome, or exome -- the regions of the genome that are translated into proteins that affect cell behavior -- has decreased significantly, to the point where the cost of looking at the majority of a patient's genomic data may be less expensive than undertaking one or two targeted genetic tests. While efficient, the acquisition of this much genetic data -- in some cases as many as 1.5 to 2 million variants -- creates other challenges.
In a paper that appears September 21 in the advance online edition of Genetics in Medicine, researchers from the University of North Carolina at Chapel Hill unveil an analysis framework aimed at helping clinicians spot "medically actionable findings" from genetic tests in an efficient manner.
"The challenge for medical geneticists is what do we do with the 'incidentalome' -- the large amount of genetic data that these tests generate which may be important but which was incidental -- that is, had nothing to do with why the patient underwent DNA analysis in the first place," said Jonathan Berg, MD, PhD, assistant professor of clinical genetics and a member of UNC Lineberger Comprehensive Cancer Center.
"Our team is faced with this issue in a clinical trial we are conducting called the NC GENES study. So we put together a framework that classifies genetic variations into three different 'bins': those that are linked to a treatable or preventable condition (the medically actionable); those that have a known link to conditions for which we don't have treatment options; and those for which there is no known direct association between a genetic variation and a disorder," he said.
The team then created an informatics approach to carry out a structured analysis on these three 'bins'.
"While there are still some challenges, we believe that this approach facilitates the analysis and streamlines the ability of the molecular analyst to go through a lot of data very quickly, providing more timely results to physicians and patients," says Berg.
Berg notes that the researchers had to set a very high bar for the genetic variants reported to patients and physicians, taking into account that there are errors in all of the current databases of known disease-causing mutations and that they contain variants that are probably not disease causing, due to unavoidable errors in data processing and other aspects of genetic research. However, because most hereditary disorders are very rare, disease causing mutations are highly unlikely.
"In epidemiologic terms we valued specificity over sensitivity. We will have some false negatives because we are ignoring some genetic variants that we don't understand well or that are very unlikely to occur. However, as researchers who also work with patients, we know that there are significant consequences to false positive results for genetic disorders and given the rarity of many of these disorders we think this is an appropriate risk," he argues.
Berg and his collaborators, which include James Evans, MD, PhD, Bryson Distinguished Professor of Genetics Research and a member of UNC Lineberger, are also studying the practical consequences of our ability to pinpoint disease-causing mutations in the genome.
"We hope that this methodology will enhance our ability to quickly translate a large amount of data into findings that are useful to physicians and patients, allowing us to study important issues like patient preference for learning about their likelihood of developing or passing along a hereditary disease for which there is no treatment," said Evans.
"These are important ethical considerations, and currently there exist no best practices because this technology is still relatively new," he added.
In addition to Berg and Evans, the research team included Michael Adams, MS, and Kristy Lee, MS from the UNC Department of Genetics, Kirk Wilhelmsen, MD, PhD from the Department of Genetics, the Carolina Center for Genome Sciences (where Berg and Evans are also members), and the Renaissance Computing Institute, and Nassib Nassar, PhD, Chris Bizon, PhD, and Charles Schmitt, PhD, from the Renaissance Computing Institute.
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The above story is reprinted from materials provided by University of North Carolina Health Care.
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Journal Reference:
- Jonathan S. Berg, Michael Adams, Nassib Nassar, Chris Bizon, Kristy Lee, Charles P. Schmitt, Kirk C. Wilhelmsen, James P. Evans. An informatics approach to analyzing the incidentalome. Genetics in Medicine, 2012; DOI: 10.1038/gim.2012.112
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/M-Vcd8t8g9w/120920120406.htm
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